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Conditions and Diseases > Immune Disorders Forum > cold antibodies and transfusions
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Q: cold antibodies and transfusions
asked by: Lailabean on July 14th, 2008
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I am a 25 y/o female. Most of my life i have had Juvenile myoclonus epilepsy. controlled well with depakote.

March 10 of this year i got the stomach bug. Throwing up and the whole 9. After about 2 days I began to recover.
March 12 i layed in bed all day shivering uncontrollably. I was so cold. The heat was on 80. I live in Georgiaand the avg temp outside at that time was 70. My muscles acked from shaking so bad, I had sweatshirts on, socks, pants, under blanket after blanket...unable to get warm.
March 13 I went to the ER thinking i had another bug. I would get some fluids, meds and go home. That was not the case. After checking my blood levels and doing many exams, pelvic, anal, blood tests etc. My white blood cells were elevated, my hematicrit was 19 and my iron was 5. Also they found cold antibodies in my blood. I was admitted and given 3 units of packed red blood cells. I was discharges the 15. a few days later had a check up. The doctor said all my levels looked good still and gave me an A OK to have a baby after my husband returned from Iraq. I became pregnant in April. The doctor said it was probobly from my menstral cycles. which were never abnormally heavy.

I went to the perinatologist . Unhappy with the transfusion is sending me to a Hemotologist/Oncologist. I go there Friday. She said she has a hunch it is an autoimmune disorder. And willmore than likely be put on Prenisone. My question is what coul it be? im so scared for my baby and myself i cant take waiting til friday. any ideas? Also where do these cold antibodies come from and what could have caused this? Any input would be helpful to ease my mind. Thanks and sorry this was so long.
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Dr. Nikola
replied on July 16th, 2008
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Are you still pregnant or you have miscarried?
What do you mean by this "... and gave me an A OK to have a baby after my husband returned from Iraq"?
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Users who thank Dr. Nikola for this post: Lailabean 
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Lailabean
replied on July 16th, 2008
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in march when i had the transfusion my husband was in iraqas he is in the army. he came hom march 29. when i went in for my check up after the transfusion the doctor said everything looked good. i asked him if we could still plan on having a baby after my husbands return and he said it was fine that everything looked good and he gave me prenatals. when my husband came home at the end of march. we tried for a baby and got pregnant the beginning of april. and yes i am still pregnant. about 14 weeks now.
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Dr. Nikola
replied on July 21st, 2008
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According to your results just before the transfusion was done, you probably had some kind of severe anemia. It is hard to believe that periods that are not very heavy can cause such anemia. Heavy periods can cause iron deficit anemia.
Cold antibodies can cause hemolytic anemia. The most important laboratory sign of hemolytic anemia is increased level of reticulocytes (young erythrocytes) in the blood. Other laboratory signs of hemolytic anemia are: increased level of free hemoglobin in the blood, increased level of indirect (not-conjugated) bilirubin in the blood, presence of hemoglobin in the urine etc. Hemolytic anemia caused by cold antibodies is considered as a autoimmune disease.
It is very important to find out the type and cause of your anemia. You can consult some hematologist about this.
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Lailabean
replied on July 21st, 2008
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i seen a hemotologist friday she said it may be cold agglutinin disease.
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Dr. Nikola
replied on July 21st, 2008
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Cold agglutinin disease is a kind of hemolytic anemia. It could be primary (idiopathic) disorder with unknown reason or secondary (symptomatic) due to other disorders (infections or some tumors).
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Lailabean
replied on July 21st, 2008
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could this cause problems with my pregnancy?
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Dr. Nikola
replied on July 23rd, 2008
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Cold agglutinin disease (CAD) by itself shouldn't cause problems with your pregnancy because cold antibodies are mostly IgM-class and they can't pass trough the placenta and get into fetal bloodstream.
Your pregnancy could be disturbed by the primary disorder that caused CAD (if your CAD is a secondary disorder) or by the mother's anemia if it is too severe.
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