Chrons Disease Meds

I have had Crohns Disease for about 2 1/2 years and have had successful treatment with Imuran, and Remicaid if Infusions. at my last appointment my doctor said I could stop taking Pentasa --- I have been without a flare-up for almost a year. I also have ADHD which I take Vyvance 70 mg on weekdays ...... My question is this: Does Imuran and Remicaid and the previous medications taken to treat my Crohnes disease make it harder for me to loose weight? I am 39 years old and have 2 children, I am 5.4' and weigh 220 lbs...... I have been able to loose weight here and there but cant keep it off..... I also recently started taking Prestique which typically patients loose an average of 10 lbs however I have not been able to loose any.... Do you have any suggestions that would help me loose some weight, I do have a treadmill and occassionally walk, however I work full time and quite often am very fatigued......

thank you very much for your time .... Teresa Pierce