I am 44 and have had chronic constipation with treated thyroid disease EVER SINCE I CAN REMEMBER (4 or 5 years old). After so many years, tried every remedy, laxative, diet, ready to get my colon removed, I started taking Cortisol for "adrenal exhaustion". Don't ask me to try another bran, prune, suppository, water, fiber drink. The constipation went away! Then I lowered the cortisol (becuase I was gaining weight), and it came back, viola. Of course, anyone who has had this for so long, you want to be sure that's what was really the cure. So I tried other things and lowered my cortisol again, and it came back. It is amazing! I NEVER had a normal bm until the cortisol! Is that what it is suppose to be like?! I believe what it does is enables the cells in my body to receive the thyroid, and so then the thyroid can regulate the bowels. So, I'm closely trying to balance all of these things, I'm still in the process. Now I am going to have my md do the ACTH stim test, since I have had this since childhood, I may have Addison's and need to know in case of severe stress. No One (md or anything I read on the internet) ever told me that this would help my constipation, they were just trying to alleviate my fatigue.