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Certain HIV positive, but negative tests (Page 85)

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July 8th, 2013
I thank everyone on this forum the support if even by simply sharing our stories and experiences. I'm not sure how many of you believe in The Lord Jesus Christ and his father but I do! As we've all come to know, there's so much a doctor can do or is even willing to do but God can do all things! He doesn't think we're crazy and it's all in our heads. In fact, he knows everything we think regardless of if we say. I encourage you all to pray, pray and never cease. There's power in united prayer so lets all keep praying for each other.
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replied July 8th, 2013
HELP!!!
Hi everyone..

I am same with you all here made the stupid mistake that made me regret.

I was tested 15-week post exposure for HIV and Hep B and the result is negative. I m sure I dont have HIV after reading all the treads here. I also tested 11-week post exposure for Syphilis, HSV1 & 2, Chlamydia and Gonorrhea. All results came back negative except HSV 1. I cant recall whether I was having cold sore during i was a child and I m worry it could be a genital herpes. But so far I dont notice any lesion or blister on my genital area.

I was diagnosis with NGU/NSU and was treated with antibiotic but up to now still having symptoms such as irritate penis tip and swollen meatus on and off. Besides, I notice a small hole or scar under the shaft that near to my penis head. Doc said it is fungus infection but it seems like wont go away after one month of treatment and this make me worry of herpes.

I am also having the following symptoms:
- something stuck in my throat
- giddiness
- tingling on hand and feet
- back pain
- muscle tweaking all over the body
- fatigue all the time

Could all these are due to HTLV infection too?
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replied July 9th, 2013
Experienced User
Hey we are sorry you have been dealing with all this. Like all of us though. How. Old r u and where r u from? Who was this exposure with?
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replied July 9th, 2013
I am 35 from singapore...had sex with a sex worker in march 2013...Now my penis head is very itchy in particular the scar/small hole that on my penis shaft that near to the penis head...Dont really what is that? Any idea from you all?
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replied July 9th, 2013
I am also having muscle tingling in my leg and thigh. Sometimes in my testis...Doctor had checked my testis and said normal and no swollen....
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replied July 9th, 2013
the following is my sexual encounter:

I rubbed my penis (Urethral Part) on her back without condom on my penis. I licked her nipple and upper part of her body and no oral sex (give or receive). Prior to penetration (but my penis did touch on her private part), i had ejaculated with condom on my penis. After that encounter, I was diagnosed with NGU but after 1 month of antibiotic treatment still having the sensation of discharge (no stain on my underwear).

I went to seek 2 opinion from other doctor and he said is NSU and took antibiotic for 2 weeks. But somehow i do not feel 100% better especially the itchiness at the small hole/scar on my shaft that near to the penis head. Really suffer.
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replied July 9th, 2013
Experienced User
March 30, 2012
New Drug Application Approval for
POTELIGEO (Mogamulizumab) Injection in Japan,
a Therapeutic Antibody for Adult T-cell Leukemia-Lymphoma (ATL)

Tokyo, Japan, March 30 2012 --- Kyowa Hakko Kirin Co., Ltd. ("Kyowa Hakko Kirin") announced today that it has received approval for a new drug application (NDA) from the Ministry of Health, Labour and Welfare (MHLW) for POTELIGEO (Mogamulizumab) Injection ("POTELIGEO") that is a therapeutic antibody for patients with relapsed or refractory CCR4-positive adult T-cell leukemia-lymphoma (ATL).
POTELIGEO is a humanized monoclonal antibody produced by applying POTELLIGENT, a technology to produce antibodies with enhanced ADCC activity, which was developed exclusively by Kyowa Hakko Kirin. This product is the first antibody for which Kyowa Hakko Kirin has an NDA approved, and is also the world's first POTELLIGENT antibody approved for marketing approval. POTELIGEO binds to CCR4 that is expressed on the surface of ATL cells. POTELIGEO was also granted an orphan drug designation for the treatment of CCR4-positive ATL by the MHLW.
Kyowa Hakko Kirin is working to provide treatment for a wide range of diseases with an unmet medical need including orphan diseases such as ATL. Kyowa Hakko Kirin will strive to contribute to the improvement of patients' QOL through the development of therapeutic antibodies using its unique antibody technologies.
Overview of POTELIGEO
Product Name POTELIGEO Injection
Generic Name USAN, INN: Mogamulizumab
Indication Relapsed or refractory CCR4-positive adult T-cell leukemia-lymphoma
Dosage and Administration Once-weekly doses (eight administrations) of 1.0 mg/kg POTELIGEO Injection.
About Adult T-cell leukemia-lymphoma (ATL)
HTLV-1 (retrovirus)-induced peripheral T-cell lymphoma. Currently, about 1150 people a year develop ATL in Japan. Generally, combination chemotherapy such as mLSG15 is used, but no curative treatment has been established for ATL, except transplantation, which is actively being studied at present. For recurrent/relapsed ATL, different types of chemotherapies are used based on the treatment of malignant lymphoma, but no effective treatment has been established.
About POTELLIGENT
Kyowa Hakko Kirin's unique technology to produce antibodies with enhanced ADCC activity. This technique allows production of antibodies that reduces the amount of fucose in the carbohydrate structure of an antibody. Non-clinical animal studies have confirmed that antibodies produced by this technology killed the target cells much more efficiently than existing antibodies and exhibited stronger antitumor effects.
About CCR4 (chemokine [C-C motif] receptor 4)
CCR4 is one of chemokine receptors involved in leukocyte migration. It is known that in normal cells, CCR4 is selectively expressed in type 2 helper T (Th2) cells that produce cytokines such as IL-4 and IL-5 (CD4-positive). It is also known that CCR4 is highly expressed in certain hematological malignancies.
About ADCC (antibody-dependent cellular cytotoxicity)
When an antibody binds to an antigen, effector cells such as macrophages and NK cells subsequently bind to the antibody. Antigen-bearing target cells are killed by these effector cells.
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replied July 9th, 2013
Experienced User
Mogamulizumab: first global approval.

Authors
Subramaniam JM, Whiteside G, McKeage K, Croxtall JC.
Journal
Drugs. 2012 Jun 18;72(9):1293-8. doi: 10.2165/11631090-000000000-00000.

Affiliation
Adis RD Insight, Auckland, New Zealand.

Abstract
Mogamulizumab (Poteligeo) is a defucosylated, humanized monoclonal antibody targeting CC chemokine receptor 4 (CCR4). Development is being carried out by its owner Kyowa Hakko Kirin for various haematological malignancies, and by licensee Amgen for asthma. Mogamulizumab was conceived through Kyowa Hakko Kirin's Potelligent technology, which produces antibodies with enhanced antibody-dependent cellular cytotoxicity. This is achieved largely by reducing fucose content in the oligosaccharide structure of the Fc region. Mogamulizumab has been approved in Japan for the treatment of relapsed or refractory adult T-cell leukaemia-lymphoma (ATL) and is the first Potelligent antibody to receive marketing approval anywhere in the world. Phase II development is underway for adult T-cell leukaemia-lymphoma (ATL) and cutaneous T-cell lymphoma in the US, and for peripheral T-cell lymphoma in the US and Europe. Amgen is conducting a phase I US-based study in patients with asthma. This article summarizes the milestones in the development of intravenous mogamulizumab leading to this first approval.
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replied July 9th, 2013
Experienced User
Also to my post.. Why isn't there any girls here?? Not one and it's meant to be transfered more from men to women than women to men. Im just confused
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replied July 9th, 2013
Extremely eHealthy
WK,

Because women are in such a state of denial about this, believe me I tried to have conversations with women about HTLV, they just won't accept that it exists and that people are getting infected with it, even when faced with serious symptoms.

Best wishes.
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replied July 9th, 2013
Extremely eHealthy
There's a new test for HTLV developed by a company called Gene ID in San Carlo, Brazil - the test was developed because of unreliability of current HTLV tests. How many of you would be willing to take such a test? I'm asking because I'm wondering if we are afraid of finding out that we have HTLV.
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replied July 9th, 2013
Experienced User
Tony are you taking the test? If so when? Does tht mean you have to go to brazil? And how good is the test?
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replied July 9th, 2013
Extremely eHealthy
1. I'd love to take it.
2. Not going to Brazil, going to see if Resperanza or someone else who speaks the language can get the test shipped to me.
3. The test is supposedly BETTER than existing tests, that's why it was developed.
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replied July 9th, 2013
Experienced User
How do you test using it? Can you do it yourself?? If so I would be interested in getting the test also...
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replied July 9th, 2013
Extremely eHealthy
I don't know, which is why I need someone who speaks the language to call there & find out how complicated or easy the test is to perform.
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replied July 9th, 2013
Experienced User
Oh fair enough. I would be Interested if it can be done..
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replied July 9th, 2013
Extremely eHealthy
Last time we discussed this, Resperanza was going to make the call, find out who much the test costs, and I was going to send him the money. I haven't heard from him in a while, so I'm not sure what happened.

Best,
George.
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replied July 9th, 2013
Experienced User
Yeh well is be willing to pay for it also. So I we can get it count me in for one. I am willing to pay ASAP if we can do it ourselves..
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replied July 9th, 2013
Extremely eHealthy
I'm willing to pay for it ASAP as well, but like I said, I haven't heard from Resperanza (who speaks their language, Portuguese).

Best wishes.
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replied July 9th, 2013
Experienced User
I will be taking all the different htlv test available to me, if i could obtain that test from Gene ID I would definitely pay for it also, so you could count me in.
I just don't know how getting the kit means we will be tested for it.
I think even if you get the kit, you have to find a lab who knows how to perform it, and not only that, but you also have to find a Dr. who is willing to request the lab to perform that test on us.
Realistically speaking it seems less far fetched to go to Brazil and be tested by somebody who regularly performs it.
None the less, let me know, because i would take the test if I could, i don't see how it would hurt.
Still the Gene ID test has been under development because its going to be use as a confirmatory test to the antibody, they currently use the WB, but they are unsatisfied because it gives a lot of inconclusive results and its an expensive imported kit to them, the new Gene ID test will be more sensative and a alot cheaper than the WB.
I would pay a good amount of money for the test.
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replied July 9th, 2013
Extremely eHealthy
DW,

I agree, and another good thing about the new test is the price, supposedly it's ten times cheaper than the other tests.

Best wishes.
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replied July 9th, 2013
Experienced User
Hope he comes back soon to let us know. Would be good to test...
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replied July 9th, 2013
Extremely eHealthy
Yes, it would be good to take that test, it's a step forward indeed.
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replied July 9th, 2013
Experienced User
I have noticed constant ringing in my ears... Is there anything I can do?
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replied July 9th, 2013
Hi everyone..

I am same with you all here made the stupid mistake that made me regret.

I was tested 15-week post exposure for HIV and Hep B and the result is negative. I m sure I dont have HIV after reading all the treads here. I also tested 11-week post exposure for Syphilis, HSV1 & 2, Chlamydia and Gonorrhea. All results came back negative except HSV 1. I cant recall whether I was having cold sore during i was a child and I m worry it could be a genital herpes. But so far I dont notice any lesion or blister on my genital area.

I was diagnosis with NGU/NSU and was treated with antibiotic but up to now still having symptoms such as irritate penis tip and swollen meatus on and off. Besides, I notice a small hole or scar under the shaft that near to my penis head. Doc said it is fungus infection but it seems like wont go away after one month of treatment and this make me worry of herpes.

I am also having the following symptoms:
- something stuck in my throat
- giddiness
- tingling on hand and feet
- back pain
- muscle tweaking all over the body
- fatigue all the time

Could all these are due to HTLV infection too?

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replied July 10th, 2013
Extremely eHealthy
Sounds like you have the same symptoms that the rest of us have been experiencing.

Best wishes.
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replied July 10th, 2013
..
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replied July 10th, 2013
Experienced User
Encore

Ur symptoms are similiar to all o ours however I don't think you were at risk. You had protected sexual intercourse?
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replied July 10th, 2013
the following is my sexual encounter:

I rubbed my penis (Urethral Part) on her back without condom on my penis. I licked her nipple and upper part of her body and no oral sex (give or receive). Prior to penetration (but my penis did touch on her private part), i had ejaculated with condom on my penis. After that encounter, I was diagnosed with NGU but after 1 month of antibiotic treatment still having the sensation of discharge (no stain on my underwear).

I went to seek 2 opinion from other doctor and he said is NSU and took antibiotic for 2 weeks. But somehow i do not feel 100% better especially the itchiness at the small hole/scar on my shaft that near to the penis head. Really suffer.
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User Profile
replied July 10th, 2013
Experienced User
Encoure,
We know how you feel, we feel the same way. We will try to help each other.
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replied July 10th, 2013
Experienced User
.
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replied July 10th, 2013
Experienced User
Tony, does your ears ring constantly?
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replied July 10th, 2013
Experienced User
Is there something I can do about it. It's really annoying..
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replied July 13th, 2013
For ringing, u should google tinnitus and see if it fits whith what u r feeling. To counter this, try listening to white noise mp3 (check at virtualdreamer dot com slash tinnitus) they offer free downloads of white noise background (rain, water, beach,etc) 2 help soothe the ears. Goodluck
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replied July 10th, 2013
Experienced User
This forum is always playing up..
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replied July 10th, 2013
Experienced User
Can't see me posts...
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replied July 11th, 2013
Experienced User
..
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