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Conditions and Diseases > Liver Disorders, Hepatitis A,B,C Forum > Causes of elevated bilirubin in the blood
Hepatitis can lead to serious liver damage. We cover basics about liver anatomy and define hepatitis here. Plus info on the different types of hepatitis....
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Q: Causes of elevated bilirubin in the blood
asked by: DoctorQuestion on June 9th, 2009
Total Serum Bilirubin,Direct Serum Bilirubin & Indirect Serum Bilirubin are all elevated & above normal range for the last one month.Can it be Gilbert's Syndrome even with Direct Bilirubin being above the normal range & being 32% of the total serum bilirubin?I have only one symptom of Gilbert's syndrome i.e. intermittant fatigue.
Is it some other liver disease or problem with some other body organ?
Is it only a psychological problem?
Please provide your valuable opinion on future dietary intake, activity level & advice regarding other medical examination or tests to be undertaken ,if any.


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Dr. Andrijana Shterjovska , MD
replied on June 15th, 2009
Liver Disorders, Hepatitis A,B,C Answer A6807


Gilbert’s syndrome is a congenital hereditary disorder in which the activity of certain enzymes involved in bilirubin metabolism is reduced. It is manifested with increased blood levels of unconjugated bilirubin. Mild jaundice might be present, but the condition is most often asymptomatic.


It is important because it might affect the liver’s potential to degrade medications and other substances, thus altering their effect in the organism.


According to the data you provided (increased levels of: total bilirubin, indirect bilirubin and direct bilirubin and previous history of hepatitis in 2003) you might be experiencing higher levels of bilirubin in the blood because of the previous damage that might have been done by the hepatitis. It is not uncommon to have raised bilirubin levels in the blood long after hepatitis.


You might want to visit a specialist for internal medicine, particularly in gastroenterohepatology. After a physical examination and additional laboratory tests (AST and ALT) and a hepatic ultrasound scan, he might be able to tell you whether the raised levels of bilirubin in the blood are caused by the hepatitis or not.




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