Trajedi, thanks for bringing up msmand dmso - I think it deserves a seperate topic of its own as it works different from hot peppers.
Tmddyan, tried pubmed? Kidding, no worries, I have read too that in pure, or high enough concentration this compound will produce burns.
Capsaicin offered some relief for my TMJ, but it is more effective for my knees and upper back/neck pain (believe or not some side as TMJ).
So it is not a miracle, but it came to found out that is close to one -
Hot peppers appear to be one of the super foods (whatever super means).
Even this site from Oprah is scientific enough to discuss capsaicin in detail:
http://www2.oprah.com/presents/2005/young/
life/life_peppers_b.jhtml
"...capsaicin is a potent anti-inflammatory, and have even pinpointed how it works to fight chronic, sub-clinical inflammation. The nuclei of human cells contain chemicals called nuclear transcription factors (NTFs), two of whichâactivator protein 1 (AP-1) and NF-kappa Bâare especially important targets when it comes to prevention of cancer and premature aging of skin. Each of these NTFs can be "activated" by ultraviolet light and free radicals: a result that produces a pro-inflammatory chain reaction that promotes premature aging and a wide variety of DEGENERATIVE DISEASES. As it turns out, nature offers several effective NTF-activation blockers, including the capsaicin in chilies, and the yellow pigment curcumin in turmeric."
It also talks about substance P. Which is "the key transmitter of pain". Substance P is how the body regulates swelling and pain throughout the trigeminal nerve.
Substance P causes nerve fibers to swell. Arthritis is often associated with increased levels of substance P, therefore, eliminating or supressing substance P production is one of the ways hot peppers work.