Although I am not afraid of needles, when I got my biopsy test for celiac disease it was pain-free. My doctor used general anesthesia and put me asleep before the procedure - they administer this using an IV. This did not bother me, but it is important for you to know they usually use butterfly needles for IVS, which are much thinner and therefor nearly pain-free. The procedure itself was an endoscopy, where they put a scope down through your esophagus into your stomach and into the small intestines to take the biopsy. Since I was under anesthesia, I didn't feel this at all. My throat was just a little sore for a day or 2 after the procedure. The biopsy itself is very very tiny so you won't even know they took one. Good luck, if you stay calm for any needles they use you will be very relieved that the procedure itself is very easy, quick, and painless. Best wishes!