baclofen, zanaflex, and of course painkillers have made a barely noticeable, completely ineffective difference in my TMD. I am completely disabled by it, unable to sleep more than an hour without causing worse-than-migraine pain attacks that include spasms down to my toes, spastic colon, and all the chronic diseases of disturbed sleep. I've just finished 3 whole vials in 3 months of Botox, each vial spread out correctly in 12 injections along the lengths of the masseters and can still chew shoe leather, except for the pain, of course! I find that when the inflammation of my jawbones, face, and facial nerves progresses to the trigeminal and meninges, Relpax helps a little. Also, the attacks are a lttle better after the Botox if I tape my nose shut, sleep on my face, and use the drugstore biteguard that has the springy wings adjustable to mouth size, although it's just noticably less bad, and still leaves me completely disabled. Also, you can't use the Botox for more than a few times or lose the masseters (I had to prove I don't have antibodies to Botox, too). I've gotten every surgery and treathment there is, am broke, and suspect that when I can no longer repair my teeth I'll be cured when they fall out! Any other options appreciated!