Intuition is your best friend, since our strongest instincts revolve around self-preservation.
Prayer and the quietness after often clear the mind enough to hear what your still, small voice is saying.
Follow it, and your instincts will lead you to the right answer. Peace will accompany your actions.
If this involves opening your mind, then by all means do that through prayer for safety and direction on what this is. Don't be afraid to read up on it, and follow your intuition, not just your body of knowledge.