Avonex injection, the numbness and tingling feelings in my hands start getting worse about 3 or 4 hrs after the injection. It is much worse in my right hand which always feels worse than the left anyway. The intensified numbness/paresthesias start easing up by the next day. If the numbness resolves, I probably would just assume it is a side effect. You could call the Avonex rep. But it has done that to my right hand every time since I started in April. k