So then why do people with low cholesterol still develop artery plaque, and some people with high cholesterol have clear arteries?
What about the Greenland Inuits? They had high levels of total cholesterol (Mean 240) and very High levels of "bad" cholesterol ( mean 170) yet they had one of the lowest death rates from CAD of any population.
Granted the Inuits had high HDL (Mean 62) and they consumed a diet rich in marine oils, but they had high cholesterol by todays guidelines.
So how can we say high cholesterol is the main factor that causes plaque formation when world populations demonstrate otherwise?
agreed, cholesterol is not the main factor. Lack of oil soluble vitamins A, D, and especially K2, plus inflammation, are more important factors.
google vitamin K2. It activates the enzyme MGP, which takes calcium out of soft tissues like arteries, heart valves, and the brain. MGP is abundant if you have adequate vitamins A and D. Without vitamin K2 as an activating cofactor, MGP is inactive and doesn't do its job.
"So then why do people with low cholesterol still develop artery plaque, and some people with high cholesterol have clear arteries?"
My reading about this lately is pointing to inflammation as a driving factor. With no chronic inflammation present the cholesterol can happily do it's important jobs. When there is inflammation then the cholesterol becomes stuck in the arterial walls forming plaques.
There is also lipoprotein(a), aka lpa, which is a known and deadly form of cholesterol that is genetic, as far as they know, and which is one of the main culprits for creating plaque. Many doctors don't measure this cholesterol and it makes sense to get this specific form measured. If it is within normal level, you can at least reject that as a cause. I have very high lpa and am trying high doses of niacin -- the only medicine known to reduce lpa. Good luck.
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