So then why do people with low cholesterol still develop artery plaque, and some people with high cholesterol have clear arteries?
What about the Greenland Inuits? They had high levels of total cholesterol (Mean 240) and very High levels of "bad" cholesterol ( mean 170) yet they had one of the lowest death rates from CAD of any population.
Granted the Inuits had high HDL (Mean 62) and they consumed a diet rich in marine oils, but they had high cholesterol by todays guidelines.
So how can we say high cholesterol is the main factor that causes plaque formation when world populations demonstrate otherwise?
"So then why do people with low cholesterol still develop artery plaque, and some people with high cholesterol have clear arteries?"
My reading about this lately is pointing to inflammation as a driving factor. With no chronic inflammation present the cholesterol can happily do it's important jobs. When there is inflammation then the cholesterol becomes stuck in the arterial walls forming plaques.
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