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Conditions and Diseases > Gout Forum > Arcoxia and Gout
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Q: Arcoxia and Gout
asked by: pegleg on June 14th, 2008
New User
I have been taking Arcoxia for a couple of years now - one a day, which if I always remember to take seems to keep most severe gout attacks away and allows me to lead a reasonable life (I have had gout for over 20 years). When I do forget to take it or run-out of supplies while travelling, my attacks are now exceedingly severe, leaving me ill for weeks stretching to months with major joint damage and multiple attack sites (usually feet, ankles, knees elbows and lower back). Has anyone else had experience with Arcoxia and this type of pattern. I am aware that the Arcoxia will probably nuke my kidneys or heart soon so need to think about plan B, whatever that may be.
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painfree
replied on June 15th, 2008
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Make sure you don't have sleep apnea. If you do, make sure you overcome it. That should have been Plan A.
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Users who thank painfree for this post: pegleg 
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pegleg
replied on June 15th, 2008
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That is an interesting reply. The main reason being that it is a trigger?
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pegleg
replied on June 15th, 2008
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OK "Painfree", I have done a search on the past postings and I have accessed your site on Apnea for which I thank you. I'll give it a try since I definitely suffer from apnea, but I can't say that attacks always trigger overnight.
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painfree
replied on June 16th, 2008
Experienced User
The gout attacks caused by sleep apnea will develop while sleeping. Once the monosodium urate crystals have formed, the body will gradually coat them with a protein compound that hides their chemical composition from the immune system so that the attack doesn't continue for the many months that the crystals remain. If the coating gets ruptured by physical or chemical stress, a new attack will be initiated, which probably will occur during waking hours, and will continue until the rupture is repaired. I recall very clearly how I developed a gout attack years ago while sitting cross-legged on the floor while working on a handyman project at home. I had put too much physical stress on the top of my foot, which is where my overnight gout attacks almost always occurred and where this daytime attack occurred also.

I view sleep apnea as more than a trigger for gout. It is a direct cause. When the oxygen depletion of sleep apnea leads to enough generation of excess uric acid fed into the blood, a gout attack will ensue almost immediately in those people who are genetically predisposed to gout.
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