No period (amenorrhea) is defined as lack of menstruation.
If a woman never got her first menstruation by age 16 years old, that is called primary amenorrhea. If women had menstruations in the past but haven’t had any menstruation for the last 6 months, that is called secondary menstruation.


PRIMARY amenorrhea can be due to:
1. Chromosome and genetic anomalies that affect the ovaries - 45%;
2. Brain disorders (usually tumors) – 15%;
3. Physiological reasons – 13%: Constitutional (late puberty), anorexia, excessive exercising;
4. Structural anomalies of the uterus (congenital) – 17%, and
5. Systemic diseases (hypothyroidism, obesity, celiacia, Chusing syndrome etc.) – 10%.


SECONDARY amenorrhea can be due to:
1. Pregnancy;
2. Hormonal contraception;
3. Fast increasing or decreasing of the body weight;
4. Excessive physical or mental stress;
5. Endocrine disorders (hypothyroidism, hyperprolactinemia, Chusing syndrome, PCOS…);
6. Ovarian damage caused by medicines or irradiation;
7. Early menopause;
8. Hypothalamus-pituitary disorders;
9. Uterus injury;
1. Hormonally active ovarian cyst or tumor, etc.
Therapy depends upon the cause. You may want to consult your gynecologist for proper treatment.