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If you have been sexually active without additional protection after coming off Depo shot (and if your fertility/ovulation has returned back after coming off Depo shot), pregnancy chances cannot be ruled out completely. If periods have been abnormal, or if you suspect chances of pregnancy, or if you develop new symptoms suggestive of pregnancy, you should consider visiting your doctor/gynecologist at the earliest for thorough examination (to confirm pregnancy related changes/signs in body) and blood/serum HCG level test (to confirm/rule out pregnancy accurately). Be in regular monitoring and follow-up with your treating doctor/gynecologist and report any new/abnormal symptoms immediately. Take adequate rest. Drink plenty of water. Maintain healthy diet.
Take care.