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Mental Health > Mental Conditions Forum > Accutane and brain function
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Q: Accutane and brain function
asked by: sci87 on May 27th, 2009
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I'm worried about the possible effects the acne drug Accutane has had on my brain. I had bad acne on my chest, back and face. Last year, I consulted a Dermatologist and he prescribed a low-dosage (35mg daily) course of Accutane. I was on Accutane for 6 months, and it cleared my acne completely. The only side effects I noticed were dry lips and dry eyes. I have been off the drug now for 6 months, and thankfully my acne has not come back. However, I was recently reading some information online about the damaging effects Accutane has on the brain. Since it is a retinoid, it affects cell proliferation and division. This supposedly results in damage to the hippocampus. Even though I haven't noticed any mental change, I am very worried that I have caused significant damage to my brain. My question is: would 6 months at 35mg/day have caused much damage? And if so, is any damage limited just to the time on the drug (i.e. is my brain susceptible to further impairment now)?

I suppose I'm overly paranoid, but I would really appreciate any response just to ease my mind.
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bejewelled
replied on June 5th, 2009
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Accutane reply
Ok - so I am in a similar boat - except I took a cocktail of psychiatric drugs which I feel damaged my brain. . I suppose that if you are still functioning ok and you are living your life to the best of your potential; and you don't feel depressed (which I think is a sideeffect of the Accutane - you'd better check this) then you should be ok. . Brain damage would have arisen, I'm guessing, at the time that you took the medication, or you would possibly have noticed something in the weeks or months after that was unusual (not within the characteristics of your normal personality or your normal abilities). So my best advice may seem trite, but it is: don't worry unless your life begins to change drastically and others notice it too. I had my whole family telling me something wasn't right and so I stopped my meds which helped. ALso, Sometimes paranoia in the everyday sense of the word, can feed into our emotions making us think we have symptoms (brain damage) that we don't. . so don't worry - but if you can't stop worrying - see a Doctor you trust. . if you are paranoid - don't look at the net for answers - it will just freak you out. .
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bejewelled
replied on June 5th, 2009
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sorry but i was so blown away by your post that i missed an important part of it >"(i.e. is my brain susceptible to further impairment now)?"

I don't know the answer to that one, and I have often wondered that myself. .for my circumstances. . so I can see where you are coming from. Well, my boyfriend was on Roaccutane , I think that's the name, for his acne and he is fine now. . he exercises everyday (he was young when he took it) and he is healthy and happy.
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Tarkin
replied on July 16th, 2009
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I just stopped accutane and am worried about the same thing too. I just read an article (Dopheidea & Morgan, 2008) that indicated that rats had difficulty learning while on accutane (they took more than 5 mg/kg/day, about 10 times your dose if you weigh 150 lbs). However, they had no problems after one month after they finished the medication.
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