Interesting Articles
Cognitive Outcomes in Patients with Frontal Lobe Epilepsy
Monday, January 3rd, 2011 by robert mckee
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A typical "cognitive profile" or defining behavioral syndrome for patients with frontal lobe epilepsy FLE has not been described. While there have been numerous reports of impaired "executive functions" in this population, the nature and severity of ... Read More
Possible Temporal Lobe Symptoms
Monday, January 3rd, 2011 by robert mckee
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Seizure disorders with behavioral disturbance, may initially be interpreted as psychiatric in origin. Many such problems relate to the temporal lobe of the brain. The features of temporal lobe epilepsy and non-epileptic dysfunction of the temporal lobe are so varied and... Read More
Temporal lobe epilepsy surgery failures: predictors of seizure recurrence, yield of reevaluation, and outcome following reoperation
Monday, January 3rd, 2011 by robert mckee
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Object The authors provide a systematic analysis of electroclinical characteristics in patients with persistent seizures following temporal lobe epilepsy TLE surgery and identify ideal candidates for reoperation. Methods The authors retrospectively reviewed the records ... Read More
Asymmetrical hippocampal connectivity in mesial temporal lobe epilepsy: evidence from resting state fMRI
Monday, January 3rd, 2011 by robert mckee
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BackgroundMesial temporal lobe epilepsy MTLE, the most common type of focal epilepsy in adults, is often caused by hippocampal sclerosis HS. Patients with HS usually present memory dysfunction, which is material-specific according to the hemisphere involved and has been... Read More
Mesial Temporal Lobe Epilepsy: Pathogenesis, Induced Rodent Models and Lesions
Monday, January 3rd, 2011 by robert mckee
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Abstract Mesial temporal lobe epilepsy MTLE, the most common epilepsy in adults, is generally intractable and is suspected to be the result of recurrent excitation or inhibition circuitry. Recurrent excitation and the development of seizures have been associated with ab... Read More
Pre-operative verbal memory fMRI predicts post-operative memory decline after left temporal lobe resection
Monday, January 3rd, 2011 by robert mckee
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Functional MRI fMRI of cognitive tasks depends on technology widely available in the clinical sphere, but has yet to show a role in the investigation of patients. We report here the first demonstration of a clinically valuable role for cognitive fMRI. Temporal lobe epil... Read More
Epileptic activity influences the lateralization of mesiotemporal fMRI activity
Monday, January 3rd, 2011 by robert mckee
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Objective To identify clinical factors contributing to the lateralization of mesiotemporal memory functions in epilepsy by using memory-activated fMRI. Methods Sixty patients aged 16 to 63 years with mesial temporal lobe epilepsy MTLE and 20 patients aged 16 to 60 years... Read More
Seizure focus affects regional language networks assessed by fMRI
Monday, January 3rd, 2011 by robert mckee
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Objective To investigate the degree of language dominance in patients with left and right hemisphere seizure foci compared to normal volunteers using a fMRI reading comprehension task. Methods Fifty patients with complex partial epilepsy, aged 8 to 56 years and 33 norma... Read More
Idiopathic generalised epilepsy: a pilot study of memory and neuronal dysfunction in the temporal lobes, assessed by magnetic resonance spectroscopy
Monday, January 3rd, 2011 by robert mckee
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Background The memory deficits in patients with temporal lobe epilepsy TLE are associated with epileptogenic lesions of the temporal lobes, especially hippocampal sclerosis. Memory deficits have been extensively studied in TLE, but the presence of pre-existing temporal ... Read More
Changing Frontal Contributions to Memory Before and After Medial Temporal Lobectomy
Monday, January 3rd, 2011 by robert mckee
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Frontal recruitment was characterized using functional magnetic resonance imaging fMRI during memory encoding in temporal lobe epilepsy TLE patients before and after unilateral medial temporal lobectomy. Twenty-four TLE patients and 12 healthy controls underwent a preop... Read More
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